Science

Compounds in Citrus Peels Functioning as Preventive Agents for Prostate Cancer

Effect of citrus peel extracts on the cellular quiescence of prostate cancer cells

A recent study has revealed that citrus peel extracts (CPE) have the potential to prevent prostate cancer from recurring in post-therapy cancer patients. A component of CPE, flavonoids, have previously been found to have anticancer effects, but appear to lack the correct structure to prevent tumors in patients with prostate cancer. This specific study found that the citric acid present in CPE was the contributing factor to its anticancer effects but mentioned that flavonoids should continue to be researched for chemopreventive benefits.

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Benjamin Caplan, MDCompounds in Citrus Peels Functioning as Preventive Agents for Prostate Cancer
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Cognitive Function in Aging Cocaine Smokers is Marginally Lower than Controls

Cognitive function in aging cocaine smokers

A recently published study looking to expose the functional status of older drug users has found that most of their cognitive abilities are equal to their peers who have never smoked cocaine, except for a marginally lower verbal comprehension. Similar studies should continue in order to determine how chronic drug users will affect or challenge public health systems in the future.

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Benjamin Caplan, MDCognitive Function in Aging Cocaine Smokers is Marginally Lower than Controls
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Treating insomnia with cannabis

Many people use cannabis to treat insomnia, as THC has proven effects. What about CBD? There are no clear, incontrovertible studies, and effects differ by the user, but there are promising results. More noticeably, certain terpenes have been shown to be quite effective, for example, Myrcene. http://bit.ly/2F9PXUp

Benjamin Caplan, MDTreating insomnia with cannabis
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Flavonoids May Provide Therapeutic Benefits for Type 2 Diabetes

A recent study has found that flavonoids isolated from Psoralea corylifolia are able to inhibit part of the insulin pathway.

Seeds of the P. corylifolia plant have been used in eastern medicine, primary in China, for years, and is now being further researched as flavonoids continue to intrigue researchers with their possible therapeutic benefits. The inhibitory activity found in this study provides evidence that flavonoids should be pursued as a potential treatment for Type-2 Diabetes.

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Benjamin Caplan, MDFlavonoids May Provide Therapeutic Benefits for Type 2 Diabetes
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New Extraction Methods for “Polyphenols” Benefits Future Research

Citrus peels waste as a source of value-added compounds- extraction and quantification of bioactive polyphenols

A recent study has exposed a more efficient, sustainable, and economically viable extraction method for polyphenols (specific active chemical compounds) from citrus peels. One such polyphenol is Naringin, a flavonoid present in lemon peels, which has been hypothesized to have anti-inflammatory and antioxidant effects, as well as, potentially, to help treat obesity. This new extraction method will allow researchers to discover more definite therapeutic effects of polyphenols in citrus peels.

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Benjamin Caplan, MDNew Extraction Methods for “Polyphenols” Benefits Future Research
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Cannabidiol (CBD) as an Adjunctive Therapy in Schizophrenia: A Multicenter Randomized Controlled Trial

A 2018 study showed that, for patients with schizophrenia, adding CBD to ongoing antipsychotic treatment reduced psychotic activity, as compared to placebo add-on

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Benjamin Caplan, MDCannabidiol (CBD) as an Adjunctive Therapy in Schizophrenia: A Multicenter Randomized Controlled Trial
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CBD reduces seizures and social deficits in a mouse model of Dravet syndrome

CBD treatment in a mouse model for Dravet Syndrome effectively reduced seizures and autism-like behaviors

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Benjamin Caplan, MDCBD reduces seizures and social deficits in a mouse model of Dravet syndrome
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Cannabinoids in Attention- Deficit/Hyperactivity Disorder: A randomized-controlled trial

In a placebo-controlled study of a cannabis oral spray in patients with ADHD, there was no significant improvement in cognitive performance, but there was a significant improvement in hyperactivity and impulsivity.

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Benjamin Caplan, MDCannabinoids in Attention- Deficit/Hyperactivity Disorder: A randomized-controlled trial
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Cannabidiol in Anxiety and Sleep: A Large Case Series

In a study of 72 psychiatric patients given CBD in capsule form, researchers found that cannabidiol successfully decreased anxiety and improved sleep over the course of three months. 

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Benjamin Caplan, MDCannabidiol in Anxiety and Sleep: A Large Case Series
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The Endocannabinoid System: A New Treatment Target for Obsessive Compulsive Disorder?

Animal models show that cannabis has anti-compulsive effects, and OCD patients say that cannabis improves their symptoms. Now scientists are asking for more research.

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Benjamin Caplan, MDThe Endocannabinoid System: A New Treatment Target for Obsessive Compulsive Disorder?
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