Science

Variations in Genes Influences Cannabis’ Acute Effects on Behavior

June 23, 2019 Addiction, Adolescents, Adverse Effects, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Cortisol, Future Medicine, Memory, Mental Health, Pain, Science, THC

CNR1 and FAAH variation and affective states induced by marijuana smoking

A recent study has revealed that variations within cannabinoid receptor 1 (CBR1) and fatty acid amide hydrolase (FAAH) influences cannabis’ acute effects on affect. Variations of CBR1 and FAAH are known to be associated with cannabis dependence. The current study now adds that the variations in genes also affect an individual’s behavior when ingesting cannabis. The results of this study provide useful information for understanding an individual’s motivation for marijuana use, as well as risks and associated behaviors.

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CNR1 and FAAH variation and affective states induced by marijuana smoking Download

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Prospective analysis of safety and efficacy of medical cannabis in a large, unselected population of patients with cancer

June 22, 2019 Cancer, Cannabinoids, Cannabis, Cannabis Science, CBD, Citizen Science, Future Medicine, History, Science, Survey, THC

In a study of 2,970 cancer patients, researchers determined that cannabis as a palliative treatment seems to be well tolerated, effective and a safe option to help patients cope with cancer-related symptoms.

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Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer Download

This paper is also stored here: http://bit.ly/2Fiid7B inside the CED Foundation Archive

Recently Identified Mechanism of Chronic Stress-Induced Pain

June 22, 2019 Addiction, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Cortisol, Depression, Future Medicine, History, Mental Health, Pain, Science, Stress, THC

Chronic Stress Is Associated with Pain Precipitation and Elevation in DeltaFosb Expression

Researchers have identified Delta-FosB, an osteosarcoma viral oncogene, as a useful molecular marker of sustained pain. The expression of Delta-FosB is significantly elevated by stress-induced pain, exposing its role in the adaptability of nerves. This study supports theories that Delta-FosB plays an important role in drug addiction, depression, and stress adaptation. The interaction between stress, depression, and pain is something that is not yet well-understood. But, as we learn more about cannabis-based medicine, many of the age-old questions about pain have become much clearer.

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Chronic Stress Is Associated with Pain Precipitation and Elevation in DeltaFosb Expression Download

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Safety and Efficacy of Medical Cannabis in Fibromyalgia

June 21, 2019 Anti-inflammatory properties, Arthritis, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CED In The News, Fibromyalgia, Future Medicine, Muscle Pain, Neuropathy, Pain, Science, THC

In a study of 367 patients, researchers investigated the safety and effectiveness of cannabis consumption to treat fibromyalgia symptoms. After treatment with cannabis, pain intensity (scale 0–10) reports reduced from a median of 9.0 to a median of 5.0. Interestingly, patients who had previously used cannabis were more likely to have treatment success, whereas patients who shared concerns about cannabis treatment were more likely to have treatment failure. A patient’s mindset can directly affect their treatment outcome.

At CED Clinic, we use the power of education to help patients feel comfortable and confident with their treatment plan.

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Safety and Efficacy of Medical Cannabis in Fibromyalgia Download

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CBD Overcomes Resistance to current treatment of Human Colorectal Cancer Cells

June 21, 2019 Aging, Cancer, Cannabis, Cannabis Science, CBD, Elderly, Future Medicine, Science

Oxaliplatin is the most commonly used drug to treat colorectal cancer (CRC), but patients often develop resistance to it. So, researchers conducted a study to determine the effect of CBD in overcoming oxaliplatin resistance in CRC cells. They found that elevated NOS3 phosphorylation is an essential part of the development of oxaliplatin resistance, and CBD successfully decreased NOS3 phosphorylation. This effect resulted in cells overcoming oxaliplatin resistance, which suggests that CBD could be a new strategy to treat colorectal cancer.

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Cannabidiol Overcomes Oxaliplatin Resistance by Enhancing NOS3- and SOD2-Induced Autophagy in Human Colorectal Cancer Cells Download

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Cannabinoid Receptors Working with Opioid Receptors

June 21, 2019 Addiction, Adolescents, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Future Medicine, Memory, Neuropathy, Opiates, Science

The locus coeruleus is a spot in the human brainstem that is integral to our responses to stress, panic, wakefulness, and sleep-wake transitions. Both the cannabinoid receptors and opioid receptors in the locus coeruleus have a synergistic relationship that, once the medical system begins to incorporate more education about cannabinoids, just might change how physicians prescribe pain medication. The interactions of the two receptor types provide a mechanism that could easily and conveniently improve pain control, provide treatments for addiction, and will likely aid those experiencing symptoms of withdrawal. Research focusing on the treatment of opioid addiction with cannabis is ongoing… but hindered by the legal status of cannabis.

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Characterization of cannabinoid-1 receptors in the locus coeruleus relationship with mu-opioid receptors Download

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Capsaicin Cream Treats Cannabinoid Hyperemesis Syndrome in Adolescents

June 20, 2019 Adolescents, Adverse Effects, Anxiety, Cannabinoids, Cannabis, Cannabis Hyperemesis Syndrome, Cannabis Science, Cannabis Use Disorder (CUD), Capsaicin, CB1, CB2, Heavy Use, Science, THC, Withdrawal

Capsaicin Cream for Treatment of CHS adolescent

Researchers have found that capsaicin cream is an effective and safe method of treating cannabinoid hyperemesis syndrome (CHS) in adolescents. Capsaicin cream has previously been shown to be effective at treating CHS in adults but adolescents have previously been treated with haloperidol, a drug known to have serious side effects. Capsaicin cream offers a much safer and more cost-effective method of treatment for adolescents.

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Capsaicin Cream for Treatment of CHS adolescent Download

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Safety and Efficacy of Medical Cannabis in Fibromyalgia

June 20, 2019 Anxiety, Behavior change, Bipolar Disorder, Cannabinoids, Cannabis, Cannabis News, Cannabis Science, CBD, Depression, Fibromyalgia, Future Medicine, Science, THC

Another study with promising results for the use of cannabis to treat chronic pain and fibromyalgia-related symptoms. A large majority of participants reported improved sleep, depression-related symptoms, quality of life and over 20% stopped or reduced the dosage of opioids. https://prn.to/2KXUQUe

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CED Foundation Archive

June 19, 2019 Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, CBD, CED In The News, Citizen Science, Science, Social Equity, Social Justice, THC

This week, CED Foundation added 77 more #cannabis studies, & 50 about #flavonoids. Read & search for free, and please consider uploading so that others may enjoy the materials you have! This week’s folder: http://bit.ly/2KYfOCF For the whole archive: http://tinyurl.com/MMJarchive

Dronabinol: antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns

June 19, 2019 Cancer, Cannabis, Cannabis Science, Dronabinol, Future Medicine, Science, Synthetic Cannabinoids, THC

Study provides rigorous data to support clinical evaluation of THC as a low-toxic therapy option in acute leukemia patients. In related work, full-spectrum, natural derivatives of cannabis may work more effectively than their pharmaceutical counterparts.

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Dronabinol Has Preferential Antileukemic Activity in Acute Lymphoblastic and Myeloid Leukemia With Lymphoid Differentiation Patterns Download

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