Cannabinoids

Cannabis constituent synergy in a mouse neuropathic pain model

June 24, 2019 Anti-inflammatory properties, Anxiety, Autoimmunity, Behavior change, Cannabinoids, Cannabis Education, Cannabis Science, CB1, CB2, CBD, Future Medicine, Muscle Pain, Neuropathy, Pain, Science, THC

In a mice-model study, researchers found that low dose THC:CBD might successfully treat neuropathic pain.

Neuropathic pain is pain caused by damage to the somatosensory nervous system. Neuropathic pain may be associated with abnormal sensations or pain from normally non-painful stimuli, for example, Phantom Limb Syndrome.

View this review (yellow link) or download:

Cannabis constituent synergy in a mouse neuropathic pain model Download

This paper is also stored here: http://bit.ly/2Fk0yw7 inside the CED Foundation Archive

To explore related information, click the keywords below:

THC Has Potential for Treating Agitation in Alzheimer’s Disease

June 24, 2019 Aging, Agitation, Alzheimer's Disease, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, Case Study, Cognition, Elderly, Future Medicine, Insomnia, Memory, Nabilone, Stigma, Synthetic Cannabinoids

In a crossover trial of 39 patients with Alzheimer’s disease, treatment with nabilone (a synthetic THC analog) was associated with significant improvement in agitation and, remarkably, cognition. Further studies should examine the effects of both THC and CBD in patients with Alzheimer’s disease because anxiety is common in dementia and may exacerbate agitation.

View this review (yellow link) or download:

Tetrahydrocannabinol Has Potential for Treating Agitation in Alzheimer’s Disease Download

This paper is also stored here: http://bit.ly/2IH2BfX inside the CED Foundation Archive

To explore related information, click the keywords below:

Analyses of Cannabinoid Signaling in the Immune System Highlights Key Questions, Challenges, and Future Directions

June 24, 2019 Adolescents, Anti-inflammatory properties, Arthritis, Autoimmunity, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Depression, Diabetes, Future Medicine, Neuropathy, Pain, Science, THC

Targeting Cannabinoid Signaling in the Immune System: “High”-ly Exciting Questions, Possibilities, and Challenges

A meta-analysis concerning the role of cannabinoid signaling in immune system regulations revealed current therapeutic benefits, challenges for future research, and exciting new directions. Among the current research, cannabinoids have already been found to suppress inflammation associated with autoimmune diseases, especially in multiple sclerosis, rheumatoid arthritis, Type-1 Diabetes, and Crohn’s Disease. Future cannabis-based therapies aim to improve immune responses to organ donation, bone marrow transplants, and skin grafts. The analysis includes challenges facing future cannabis research such as potential side effects and legal status.

View this review (yellow link) or download:

Targeting Cannabinoid Signaling in the Immune System- “High”-ly Exciting Questions, Possibilities, and Challenges Download

This paper is also stored here: http://bit.ly/31ArGR9 inside the CED Foundation Archive

To explore related information, click the keywords below:

Variations in Genes Influences Cannabis’ Acute Effects on Behavior

June 23, 2019 Addiction, Adolescents, Adverse Effects, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Cortisol, Future Medicine, Memory, Mental Health, Pain, Science, THC

CNR1 and FAAH variation and affective states induced by marijuana smoking

A recent study has revealed that variations within cannabinoid receptor 1 (CBR1) and fatty acid amide hydrolase (FAAH) influences cannabis’ acute effects on affect. Variations of CBR1 and FAAH are known to be associated with cannabis dependence. The current study now adds that the variations in genes also affect an individual’s behavior when ingesting cannabis. The results of this study provide useful information for understanding an individual’s motivation for marijuana use, as well as risks and associated behaviors.

View this review (yellow link) or download:

CNR1 and FAAH variation and affective states induced by marijuana smoking Download

This paper is also stored here: http://bit.ly/31Ce9Za inside the CED Foundation Archive

To explore related information, click the keywords below:

Prospective analysis of safety and efficacy of medical cannabis in a large, unselected population of patients with cancer

June 22, 2019 Cancer, Cannabinoids, Cannabis, Cannabis Science, CBD, Citizen Science, Future Medicine, History, Science, Survey, THC

In a study of 2,970 cancer patients, researchers determined that cannabis as a palliative treatment seems to be well tolerated, effective and a safe option to help patients cope with cancer-related symptoms.

View this review (yellow link) or download:

Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer Download

This paper is also stored here: http://bit.ly/2Fiid7B inside the CED Foundation Archive

Recently Identified Mechanism of Chronic Stress-Induced Pain

June 22, 2019 Addiction, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Cortisol, Depression, Future Medicine, History, Mental Health, Pain, Science, Stress, THC

Chronic Stress Is Associated with Pain Precipitation and Elevation in DeltaFosb Expression

Researchers have identified Delta-FosB, an osteosarcoma viral oncogene, as a useful molecular marker of sustained pain. The expression of Delta-FosB is significantly elevated by stress-induced pain, exposing its role in the adaptability of nerves. This study supports theories that Delta-FosB plays an important role in drug addiction, depression, and stress adaptation. The interaction between stress, depression, and pain is something that is not yet well-understood. But, as we learn more about cannabis-based medicine, many of the age-old questions about pain have become much clearer.

View this review (yellow link) or download:

Chronic Stress Is Associated with Pain Precipitation and Elevation in DeltaFosb Expression Download

This paper is also stored here: http://bit.ly/31A7Y86 inside the CED Foundation Archive

To explore related information, click the keywords below:

Tweet:

Pregnant women are using more cannabis over time

June 21, 2019 Adverse Effects, Cannabinoids, Cannabis Education, Cannabis News, Cannabis Science, CB1, CB2, CBD, Citizen Science, Future Medicine, News, Pregnancy, Regulation, Stigma, THC, Women in Cannabis

Statistics show that in the past 15 years, the number of pregnant women using marijuana, especially in their first trimester, has risen greatly. These numbers may be slightly skewed, but they show the importance of more research being done on the effect of cannabis on pregnant women. https://cnn.it/2WWQV1e

View this review (yellow link) or download:

This paper is also stored here: http://bit.ly/2IwLxcp inside the CED Foundation Archive

To explore related information, click the keywords below:

Safety and Efficacy of Medical Cannabis in Fibromyalgia

June 21, 2019 Anti-inflammatory properties, Arthritis, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CED In The News, Fibromyalgia, Future Medicine, Muscle Pain, Neuropathy, Pain, Science, THC

In a study of 367 patients, researchers investigated the safety and effectiveness of cannabis consumption to treat fibromyalgia symptoms. After treatment with cannabis, pain intensity (scale 0–10) reports reduced from a median of 9.0 to a median of 5.0. Interestingly, patients who had previously used cannabis were more likely to have treatment success, whereas patients who shared concerns about cannabis treatment were more likely to have treatment failure. A patient’s mindset can directly affect their treatment outcome.

At CED Clinic, we use the power of education to help patients feel comfortable and confident with their treatment plan.

View this review (yellow link) or download:

Safety and Efficacy of Medical Cannabis in Fibromyalgia Download

This paper is also stored here: http://bit.ly/2WWLyz6 inside the CED Foundation Archive

To explore related information, click the keywords below:

Tetrahydrocannabinol and cannabidiol as potential curative agents for cancer. A critical examination of the preclinical literature.

June 21, 2019 Animal Model, Cancer, Cannabinoids, Cannabis Science, CBD, Future Medicine, THC

According to multiple mouse-models, THC administered directly into cancerous tumors produces a reduction in tumor sizes.

View this review (yellow link) or download:

∆ 9 -tetrahydrocannabinol and cannabidiol as potential curative agents for cancer. A critical examination of the preclinical literature Download

This paper is also stored here: http://bit.ly/2FfKagk inside the CED Foundation Archive

To explore related information, click the keywords below:

Cannabinoid Receptors Working with Opioid Receptors

June 21, 2019 Addiction, Adolescents, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Future Medicine, Memory, Neuropathy, Opiates, Science

The locus coeruleus is a spot in the human brainstem that is integral to our responses to stress, panic, wakefulness, and sleep-wake transitions. Both the cannabinoid receptors and opioid receptors in the locus coeruleus have a synergistic relationship that, once the medical system begins to incorporate more education about cannabinoids, just might change how physicians prescribe pain medication. The interactions of the two receptor types provide a mechanism that could easily and conveniently improve pain control, provide treatments for addiction, and will likely aid those experiencing symptoms of withdrawal. Research focusing on the treatment of opioid addiction with cannabis is ongoing… but hindered by the legal status of cannabis.

View this review (yellow link) or download:

Characterization of cannabinoid-1 receptors in the locus coeruleus relationship with mu-opioid receptors Download

This paper is also stored here: http://bit.ly/2MMeYeK inside the CED Foundation Archive

To explore related information, click the keywords below: