Cannabinoids

The Cannabinoid System is a Promising Source of Targets for Treating Pain

June 28, 2019 Addiction, Adverse Effects, Anti-inflammatory properties, Anxiety, Arthritis, Autoimmunity, Blood-Levels, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Citizen Science, Cognition, Elderly, Future Medicine, Memory, Multiple Sclerosis, Muscle Pain, Neuropathy, Occasional Use, Opiates, Overdose, Pain, Placebo-Controlled, Products, Regulation, Science, Stigma, Stress, THC

A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain ECS

The cannabinoid system provides momentum to develop cannabinoid-based medications to treat inflammatory and neuropathic pain as researchers continue to find promising therapeutic targets. These new targets may lead to the formation of novel pain-relief medications that may serve well to alleviate pain for those suffering from cancer, multiple sclerosis, and fibromyalgia. Cannabis-based pain medicine is also being researched for opioid-sparing effects and effectiveness in reducing the necessary dose of opioids.

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A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain ECS Download

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Cannabidiol May Provide Novel Treatment for Rare Ovarian Cancer

June 27, 2019 Aging, Cancer, Cannabinoids, Cannabis Science, Case Study, CBD, Citizen Science, Elderly, Flavonoids, Future Medicine, Ovarian Cancer, Science, Terpenes

Dramatic response to Laetrile and cannabidiol (CBD) oil in a patient with metastatic low grade serous ovarian carcinoma

A recent case study has examined a patient’s response to the consumption of cannabidiol (CBD) as a treatment for a rare type of ovarian cancer. Rather than participate in chemotherapy, which has been shown to only be effective in 5% of patients with low grade serous ovarian carcinoma, an 81-year-old decided to take a combination of amygdalin and CBD. Although CBD has only been shown to have effective anti-cancer properties in murine models the featured patient reported a significant decrease in tumor size, revealing that CBD may, in fact, be an effective treatment for patients looking into alternative care methods.

Although proven ineffective, the use of amygdalin highlights alternative therapies derived from naturally occurring chemicals found in common plants. Flavonoids and terpenes are chemical components of cannabis plants, also found in a variety of fruits and vegetables, that are just now being investigated for their therapeutic benefits. The results of those inquiries may prove useful for similar patients suffering from illnesses that are resistant to the usual treatments.

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Dramatic response to Laetrile and cannabidiol (CBD) oil in a patient with metastatic low grade serous ovarian carcinoma Download

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In MA, despite being state-legal, FDA says CBD cannot be added to food or dietary supplements. What now?

June 26, 2019 Business of Cannabis, Cannabinoids, Cannabis, Cannabis News, Dispensaries, Financial Projections, Future Medicine, History, Law, Legislation, Massachusetts, Politics, Regulation, Social Justice, Stigma

MA effectively outlawed the sale of any food products with CBD or products which make therapeutic claims. This is the result of FDA saying that CBD cannot be added to food or dietary supplements. In a state where cannabis is legally accessible, consumers and hemp farmers are very unhappy. What do you think? http://bit.ly/2IOtTRm

Case Studies Reveal Difficulties in Differences between State Cannabis Laws

June 26, 2019 Blood-Levels, Cannabinoids, Cannabis News, Cannabis Science, Case Study, Future Medicine, History, Law, Legislation, Nebraska, Pediatrics, Seizure / Epilepsy, Social Justice, Stigma

Crossing the Line: Care of a Pediatric Patient with Intractable Seizures and Severe Neuropathic Pain in Absence of Access to Medical Marijuana

A recent case report discussing a six-year-old patient suffering from a seizure disorder has exposed the difficulty is receiving treatment across state lines. The patient was prescribed medical marijuana that alleviated the severity and duration of her seizures but was weaned off that medication when traveling to Nebraska for a therapeutic surgery due to the legal status in the state. This case study exposes the difficulty of treating patients across the country due to the legal variability of cannabis across states.

An interesting question brought up in this case study is how to handle palliative care in the absence of opioids and without synthetic products. A combination of massage, essential oils, and salt light therapies were able to compensate for medical marijuana, but not without great effort. Natural therapies like the ones administered here are costly and highlight the simplicity and effectiveness of medicinal cannabis.

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Crossing the Line: Care of a Pediatric Patient with Intractable Seizures and Severe Neuropathic Pain in Absence of Access to Medical Marijuana Download

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Video: The Endocannabinoid System’s Intriguing Role in Gut Health

June 26, 2019 Animal Model, Anti-inflammatory properties, Antibiotic, Autoimmunity, Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, CB1, CB2, CBD, Future Medicine, Gastrointestinal Effects, IBS, Neuropathy, Science, Stress, THC, Video

A 2018 literature review summarizes the findings on cannabis and gut health. The endocannabinoid system plays a key role in gut motility, obesity, and inflammatory bowel disease (IBD). Targeting the endocannabinoid system with CBD oil or other cannabinoids seems to reduce colonic inflammation and relieve stress, at a microscopic level, inside the gastrointestinal tract. Watch our video adaptation of the effects of cannabis on IBD:

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CBD antibacterial properties, topically

June 25, 2019 Anti-inflammatory properties, Antibiotic, Cannabinoids, Cannabis News, Cannabis Science, Case Study, CB1, CB2, CBD, Flavonoids, Future Medicine, Infectious Disease, Products, Science, THC

Preliminary testing shows positive results towards using CBD as an antibiotic topically, but also potentially to deal with systematic infections, such as pneumonia, using oral dosing. One of the present concerns is the struggle of getting permits to handle these cannabinoids to do further testing.

While these specific findings have not yet been published in a peer-review journal, this is far from the first time we have seen antimicrobial activity associated with plants or with cannabis. Evolutionarily, this trait is believed to be adaptive for the plant, and within cannabinoid, terpenoid, and flavonoid compounds, this activity has been demonstrated reproducibly, both in the lab and in clinic.
http://bit.ly/2LbTwxm

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Cannabinoids + opioid pain relief: subjective effects in healthy humans

June 25, 2019 Anti-inflammatory properties, Arthritis, Cannabinoids, Cannabis Science, Case Study, Dronabinol, Muscle Pain, Neuropathy, Opiates, Pain, Science, Synthetic Cannabinoids, THC

Human study finds that, when taken with opioids, dronabinol (THC) may increase impairment and decrease, or not affect, pain relief. Researchers conclude that THC might NOT protect the body from the adverse effects of opioids. However, the study examined only 10 participants, and such a small sample size should give pause to the validity and applicability of the findings.

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Cannabinoid modulation of opioid analgesia and subjective drug effects in healthy humans Download

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Video: Cannabis and Multiple Sclerosis

June 24, 2019 Adverse Effects, Aging, Anti-inflammatory properties, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, CB1, CB2, CBD, CED Clinic, Dr Caplan, Future Medicine, Insomnia, Multiple Sclerosis, Muscle Pain, Neuropathy, Pain, Science, Sleep, Stigma, THC, Video

A 2019 literature review summarizes the findings on cannabis use for patients with multiple sclerosis. Cannabis has been shown to aid a number of symptoms associated with multiple sclerosis, including chronic pain, spasticity, and problems with sleep. To learn more, check out our video adaptation below:

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Cannabis and Multiple Sclerosis Download

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Should donors who have used marijuana be considered candidates for living kidney donation?

June 24, 2019 Adverse Effects, Anti-inflammatory properties, Cannabinoids, Cannabis, Cannabis News, Cannabis Science, Future Medicine, Organ Donation, Social Justice, Stigma, Testing

Although tobacco use has been linked to worse outcomes for kidney donors and recipients, cannabis seems to have no effect on post-operation outcomes.

In a retrospective study of 294 kidney transplants, doctors found no short-term or long-term differences in kidney function for donors or recipients.

In other words, cannabis users may safely donate kidneys.

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Should donors who have used marijuana be considered candidates for living kidney donation?Download

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Complex Genetics Underlie Cannabinoid Production

June 24, 2019 Cannabinoids, Cannabis, Cannabis Science, Cultivation, Extraction, Flavonoids, Future Medicine, Genetics, History, Non-Cannabis Plant, Science, Terpenes

Cannabinoid Inheritance Relies on Complex Genetic Architecture

Researchers have recently attempted to discover the genetic basis of cannabinoid production within cannabis plants, finding a complex genetic architecture. This study highlights the lack of knowledge surrounding cannabis cultivation, suggesting current producers record the phenotypic and genetic crosses they breed so that the community can further research the cannabinoids produced. Specifying which genetic profiles match up to the ratio of cannabinoids produced will benefit mass production and medical research.

The introduction of this article focuses heavily on the ratio of ∆-9-tetrahydrocannabinol to cannabidiol, yet there are therapeutic benefits associated with all of the other cannabinoids as well as flavonoids and terpenes produced by the plant. Multiple chemical components of cannabis strains have yet to be fully explored and preliminary findings warrant the same amount of attention in order to develop various therapies.

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Cannabinoid Inheritance Relies on Complex Genetic Architecture Download

This paper is also stored here: http://bit.ly/2L3PeIl inside the CED Foundation Archive