All posts tagged: Science

Case Studies Expose Under Recognition of Cannabis Hyperemesis Syndrome

June 25, 2019 Adverse Effects, Cannabis Hyperemesis Syndrome, Cannabis Use Disorder (CUD), Capsaicin, Case Study, Citizen Science, Heavy Use, Science

“Cannabis hyperemesis syndrome: still under-recognized after all these years“

After two years of chronic vomiting and pain and dozens of trips to emergency rooms a 23-year-old woman was found to have cannabis hyperemesis syndrome (CHS). Physicians are still unable to recognize the early symptoms of CHS as cannabis use is still in a legal gray area in much of the country. A lack of research, recognition, and trust often prevents a quick diagnosis when an illness is related to cannabis, leading to multiple referrals and invasive tests.

CHS was first described 15 years ago yet it is not frequently recognized in patients. The case study featured in this blog post highlights patients and physicians’ outcry for tolerance and support so that cannabis-related illnesses can be efficiently and effectively engaged.

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Cannabis hyperemesis syndrome: still under recognised after all these years Download

This paper is also stored here: http://bit.ly/2IxMxNx inside the CED Foundation Archive

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Video: Cannabis and Multiple Sclerosis

June 24, 2019 Adverse Effects, Aging, Anti-inflammatory properties, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, CB1, CB2, CBD, CED Clinic, Dr Caplan, Future Medicine, Insomnia, Multiple Sclerosis, Muscle Pain, Neuropathy, Pain, Science, Sleep, Stigma, THC, Video

A 2019 literature review summarizes the findings on cannabis use for patients with multiple sclerosis. Cannabis has been shown to aid a number of symptoms associated with multiple sclerosis, including chronic pain, spasticity, and problems with sleep. To learn more, check out our video adaptation below:

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Cannabis and Multiple Sclerosis Download

This paper is also stored here: http://bit.ly/2IJAqNz inside the CED Foundation Archive

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Complex Genetics Underlie Cannabinoid Production

June 24, 2019 Cannabinoids, Cannabis, Cannabis Science, Cultivation, Extraction, Flavonoids, Future Medicine, Genetics, History, Non-Cannabis Plant, Science, Terpenes

Cannabinoid Inheritance Relies on Complex Genetic Architecture

Researchers have recently attempted to discover the genetic basis of cannabinoid production within cannabis plants, finding a complex genetic architecture. This study highlights the lack of knowledge surrounding cannabis cultivation, suggesting current producers record the phenotypic and genetic crosses they breed so that the community can further research the cannabinoids produced. Specifying which genetic profiles match up to the ratio of cannabinoids produced will benefit mass production and medical research.

The introduction of this article focuses heavily on the ratio of ∆-9-tetrahydrocannabinol to cannabidiol, yet there are therapeutic benefits associated with all of the other cannabinoids as well as flavonoids and terpenes produced by the plant. Multiple chemical components of cannabis strains have yet to be fully explored and preliminary findings warrant the same amount of attention in order to develop various therapies.

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Cannabinoid Inheritance Relies on Complex Genetic Architecture Download

This paper is also stored here: http://bit.ly/2L3PeIl inside the CED Foundation Archive

Cannabis constituent synergy in a mouse neuropathic pain model

June 24, 2019 Anti-inflammatory properties, Anxiety, Autoimmunity, Behavior change, Cannabinoids, Cannabis Education, Cannabis Science, CB1, CB2, CBD, Future Medicine, Muscle Pain, Neuropathy, Pain, Science, THC

In a mice-model study, researchers found that low dose THC:CBD might successfully treat neuropathic pain.

Neuropathic pain is pain caused by damage to the somatosensory nervous system. Neuropathic pain may be associated with abnormal sensations or pain from normally non-painful stimuli, for example, Phantom Limb Syndrome.

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Cannabis constituent synergy in a mouse neuropathic pain model Download

This paper is also stored here: http://bit.ly/2Fk0yw7 inside the CED Foundation Archive

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Analyses of Cannabinoid Signaling in the Immune System Highlights Key Questions, Challenges, and Future Directions

June 24, 2019 Adolescents, Anti-inflammatory properties, Arthritis, Autoimmunity, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Depression, Diabetes, Future Medicine, Neuropathy, Pain, Science, THC

Targeting Cannabinoid Signaling in the Immune System: “High”-ly Exciting Questions, Possibilities, and Challenges

A meta-analysis concerning the role of cannabinoid signaling in immune system regulations revealed current therapeutic benefits, challenges for future research, and exciting new directions. Among the current research, cannabinoids have already been found to suppress inflammation associated with autoimmune diseases, especially in multiple sclerosis, rheumatoid arthritis, Type-1 Diabetes, and Crohn’s Disease. Future cannabis-based therapies aim to improve immune responses to organ donation, bone marrow transplants, and skin grafts. The analysis includes challenges facing future cannabis research such as potential side effects and legal status.

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Targeting Cannabinoid Signaling in the Immune System- “High”-ly Exciting Questions, Possibilities, and Challenges Download

This paper is also stored here: http://bit.ly/31ArGR9 inside the CED Foundation Archive

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Variations in Genes Influences Cannabis’ Acute Effects on Behavior

June 23, 2019 Addiction, Adolescents, Adverse Effects, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Cortisol, Future Medicine, Memory, Mental Health, Pain, Science, THC

CNR1 and FAAH variation and affective states induced by marijuana smoking

A recent study has revealed that variations within cannabinoid receptor 1 (CBR1) and fatty acid amide hydrolase (FAAH) influences cannabis’ acute effects on affect. Variations of CBR1 and FAAH are known to be associated with cannabis dependence. The current study now adds that the variations in genes also affect an individual’s behavior when ingesting cannabis. The results of this study provide useful information for understanding an individual’s motivation for marijuana use, as well as risks and associated behaviors.

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CNR1 and FAAH variation and affective states induced by marijuana smoking Download

This paper is also stored here: http://bit.ly/31Ce9Za inside the CED Foundation Archive

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Prospective analysis of safety and efficacy of medical cannabis in a large, unselected population of patients with cancer

June 22, 2019 Cancer, Cannabinoids, Cannabis, Cannabis Science, CBD, Citizen Science, Future Medicine, History, Science, Survey, THC

In a study of 2,970 cancer patients, researchers determined that cannabis as a palliative treatment seems to be well tolerated, effective and a safe option to help patients cope with cancer-related symptoms.

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Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer Download

This paper is also stored here: http://bit.ly/2Fiid7B inside the CED Foundation Archive

Recently Identified Mechanism of Chronic Stress-Induced Pain

June 22, 2019 Addiction, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Cortisol, Depression, Future Medicine, History, Mental Health, Pain, Science, Stress, THC

Chronic Stress Is Associated with Pain Precipitation and Elevation in DeltaFosb Expression

Researchers have identified Delta-FosB, an osteosarcoma viral oncogene, as a useful molecular marker of sustained pain. The expression of Delta-FosB is significantly elevated by stress-induced pain, exposing its role in the adaptability of nerves. This study supports theories that Delta-FosB plays an important role in drug addiction, depression, and stress adaptation. The interaction between stress, depression, and pain is something that is not yet well-understood. But, as we learn more about cannabis-based medicine, many of the age-old questions about pain have become much clearer.

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Chronic Stress Is Associated with Pain Precipitation and Elevation in DeltaFosb Expression Download

This paper is also stored here: http://bit.ly/31A7Y86 inside the CED Foundation Archive

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Safety and Efficacy of Medical Cannabis in Fibromyalgia

June 21, 2019 Anti-inflammatory properties, Arthritis, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CED In The News, Fibromyalgia, Future Medicine, Muscle Pain, Neuropathy, Pain, Science, THC

In a study of 367 patients, researchers investigated the safety and effectiveness of cannabis consumption to treat fibromyalgia symptoms. After treatment with cannabis, pain intensity (scale 0–10) reports reduced from a median of 9.0 to a median of 5.0. Interestingly, patients who had previously used cannabis were more likely to have treatment success, whereas patients who shared concerns about cannabis treatment were more likely to have treatment failure. A patient’s mindset can directly affect their treatment outcome.

At CED Clinic, we use the power of education to help patients feel comfortable and confident with their treatment plan.

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Safety and Efficacy of Medical Cannabis in Fibromyalgia Download

This paper is also stored here: http://bit.ly/2WWLyz6 inside the CED Foundation Archive

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CBD Overcomes Resistance to current treatment of Human Colorectal Cancer Cells

June 21, 2019 Aging, Cancer, Cannabis, Cannabis Science, CBD, Elderly, Future Medicine, Science

Oxaliplatin is the most commonly used drug to treat colorectal cancer (CRC), but patients often develop resistance to it. So, researchers conducted a study to determine the effect of CBD in overcoming oxaliplatin resistance in CRC cells. They found that elevated NOS3 phosphorylation is an essential part of the development of oxaliplatin resistance, and CBD successfully decreased NOS3 phosphorylation. This effect resulted in cells overcoming oxaliplatin resistance, which suggests that CBD could be a new strategy to treat colorectal cancer.

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Cannabidiol Overcomes Oxaliplatin Resistance by Enhancing NOS3- and SOD2-Induced Autophagy in Human Colorectal Cancer Cells Download

This paper is also stored here: http://bit.ly/2IwfVn9 inside the CED Foundation Archive

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