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Recently Identified Mechanism of Chronic Stress-Induced Pain

June 22, 2019 , , , , , , , , , , , , , , , ,

Chronic Stress Is Associated with Pain Precipitation and Elevation in DeltaFosb Expression

Researchers have identified Delta-FosB, an osteosarcoma viral oncogene, as a useful molecular marker of sustained pain. The expression of Delta-FosB is significantly elevated by stress-induced pain, exposing its role in the adaptability of nerves. This study supports theories that Delta-FosB plays an important role in drug addiction, depression, and stress adaptation. The interaction between stress, depression, and pain is something that is not yet well-understood. But, as we learn more about cannabis-based medicine, many of the age-old questions about pain have become much clearer.

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Chronic Stress Is Associated with Pain Precipitation and Elevation in DeltaFosb ExpressionDownload

This paper is also stored here:   http://bit.ly/31A7Y86      inside the CED Foundation Archive

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Benjamin Caplan, MDRecently Identified Mechanism of Chronic Stress-Induced Pain
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Vaping cannabis among adolescents: prevalence and associations with tobacco use from a cross-sectional study in the USA

June 21, 2019 , , , , , , , , , , ,

Out of 2,835 high school students from North Carolina, 272 students (or 9.6%) reported ever vaping cannabis. Interestingly, the odds of ever vaping cannabis were significantly higher among males (11.0%) compared with females (8.2%), and significantly higher among non-Hispanic white students (11.3%) compared with non-Hispanic black students (5.0%).

It’s clear that white males are the most likely to have ever vaping cannabis. Why might minority students engage less with recreational drug use?

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Vaping cannabis among adolescents- prevalence and associations with tobacco use from a cross-sectional study in the USADownload

This paper is also stored here:    http://bit.ly/2L6zYdv     inside the CED Foundation Archive

Benjamin Caplan, MDVaping cannabis among adolescents: prevalence and associations with tobacco use from a cross-sectional study in the USA
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Safety and Efficacy of Medical Cannabis in Fibromyalgia

June 21, 2019 , , , , , , , , , , , , , ,

In a study of 367 patients, researchers investigated the safety and effectiveness of cannabis consumption to treat fibromyalgia symptoms. After treatment with cannabis, pain intensity (scale 0–10) reports reduced from a median of 9.0 to a median of 5.0. Interestingly, patients who had previously used cannabis were more likely to have treatment success, whereas patients who shared concerns about cannabis treatment were more likely to have treatment failure. A patient’s mindset can directly affect their treatment outcome.

At CED Clinic, we use the power of education to help patients feel comfortable and confident with their treatment plan.

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Safety and Efficacy of Medical Cannabis in FibromyalgiaDownload

This paper is also stored here:     http://bit.ly/2WWLyz6    inside the CED Foundation Archive

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Benjamin Caplan, MDSafety and Efficacy of Medical Cannabis in Fibromyalgia
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Profile of Dr Caplan, Dr Grinspoon, CED Clinic, and modern Medical Cannabis in Alcoholism & Drug Abuse Weekly

June 21, 2019 , , , , , , , , , , , , , , , , , , , ,

The esteemed medical periodical, Alcoholism & Drug Abuse Weekly, takes a closer look at modern medical cannabis with Dr Grinspoon and I. Our discussion brings an insider’s look at how the system operates, from clinic to dispensary, the dynamic changes we’ve already seen and highlights some of the changes to come. Included are The Role of Medicine, The Ethics of doctors in business, The Patient Experience, Physician’s Support, Growing the Plant, and a sit-down with a local dispensary.

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ADAW-June-24-2019Download

This paper is also stored here:     http://bit.ly/2Lc2H0R    inside the CED Foundation Archive

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Benjamin Caplan, MDProfile of Dr Caplan, Dr Grinspoon, CED Clinic, and modern Medical Cannabis in Alcoholism & Drug Abuse Weekly
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CBD Overcomes Resistance to current treatment of Human Colorectal Cancer Cells

June 21, 2019 , , , , , , ,

Oxaliplatin is the most commonly used drug to treat colorectal cancer (CRC), but patients often develop resistance to it. So, researchers conducted a study to determine the effect of CBD in overcoming oxaliplatin resistance in CRC cells. They found that elevated NOS3 phosphorylation is an essential part of the development of oxaliplatin resistance, and CBD successfully decreased NOS3 phosphorylation. This effect resulted in cells overcoming oxaliplatin resistance, which suggests that CBD could be a new strategy to treat colorectal cancer. 

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Cannabidiol Overcomes Oxaliplatin Resistance by Enhancing NOS3- and SOD2-Induced Autophagy in Human Colorectal Cancer CellsDownload

This paper is also stored here:    http://bit.ly/2IwfVn9     inside the CED Foundation Archive

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Benjamin Caplan, MDCBD Overcomes Resistance to current treatment of Human Colorectal Cancer Cells
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Cannabinoid Receptors Working with Opioid Receptors

June 21, 2019 , , , , , , , , , , , , , , ,

The locus coeruleus is a spot in the human brainstem that is integral to our responses to stress, panic, wakefulness, and sleep-wake transitions. Both the cannabinoid receptors and opioid receptors in the locus coeruleus have a synergistic relationship that, once the medical system begins to incorporate more education about cannabinoids, just might change how physicians prescribe pain medication. The interactions of the two receptor types provide a mechanism that could easily and conveniently improve pain control, provide treatments for addiction, and will likely aid those experiencing symptoms of withdrawal. Research focusing on the treatment of opioid addiction with cannabis is ongoing… but hindered by the legal status of cannabis.

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Characterization of cannabinoid-1 receptors in the locus coeruleus relationship with mu-opioid receptorsDownload

This paper is also stored here:     http://bit.ly/2MMeYeK    inside the CED Foundation Archive

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Benjamin Caplan, MDCannabinoid Receptors Working with Opioid Receptors
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Public Cannabis Consumption Now Allowed In Colombia… Is Full Marijuana Legalization Next?

June 21, 2019 , , , , , ,

This week, Colombia’s Constitutional Court overruled a ban on the public consumption of cannabis. Now, citizens wonder if the government will soon legalize recreational cannabis in addition to the already-legal medical cannabis. 

https://www.forbes.com/sites/javierhasse/2019/06/19/colombia-public-cannabis-consumption/#22612e3229e9

Benjamin Caplan, MDPublic Cannabis Consumption Now Allowed In Colombia… Is Full Marijuana Legalization Next?
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Cannabis sales could hit $15 billion globally this year

June 21, 2019 , , , , ,

Fueled by CBD product sales and Canada’s recent legalization of marijuana, the world’s cannabis market could total $14.9 billion in 2019, up 36% from 2018, according to a new report released Thursday.

https://www.cnn.com/2019/06/20/tech/cannabis-industry-15-billion/index.html

Benjamin Caplan, MDCannabis sales could hit $15 billion globally this year
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Capsaicin Cream Treats Cannabinoid Hyperemesis Syndrome in Adolescents

June 20, 2019 , , , , , , , , , , , , , ,

Capsaicin Cream for Treatment of CHS adolescent

Researchers have found that capsaicin cream is an effective and safe method of treating cannabinoid hyperemesis syndrome (CHS) in adolescents. Capsaicin cream has previously been shown to be effective at treating CHS in adults but adolescents have previously been treated with haloperidol, a drug known to have serious side effects. Capsaicin cream offers a much safer and more cost-effective method of treatment for adolescents.

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Capsaicin Cream for Treatment of CHS adolescentDownload

This paper is also stored here:   http://bit.ly/2F8Gtcc      inside the CED Foundation Archive

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Benjamin Caplan, MDCapsaicin Cream Treats Cannabinoid Hyperemesis Syndrome in Adolescents
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Cannabinoid Hyperemesis Syndrome is Frequently Misdiagnosed as Cyclic Vomiting Syndrome

June 20, 2019 , , , , , , , , , , , ,

Association of Marijuana Use and Cyclic Vomiting Syndrome

A recent study has found that a subset of patients diagnosed with Cyclic Vomiting Syndrome actually suffers from Cannabinoid Hyperemesis Syndrome. Cannabinoid Hyperemesis Syndrome is a rare condition that primarily occurs in daily, long-term users of cannabis, more common among males than females. Chronic cannabis consumers should inform their physicians of any illicit drug use, as well as any cannabis consumption, during routine check-ups and/or emergency room visits, to ensure accurate diagnoses can be made.

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Association of Marijuana Use and Cyclic Vomiting SyndromeDownload

This paper is also stored here:   http://bit.ly/2F9YS8u      inside the CED Foundation Archive

To explore related information, click the keywords below:

Benjamin Caplan, MDCannabinoid Hyperemesis Syndrome is Frequently Misdiagnosed as Cyclic Vomiting Syndrome
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