Cannabinoids

Some, But Not Enough Data on Cannabis for Chronic Pain

Overlaps in pharmacology for the treatment of chronic pain and mental health disorders

Select small trials have demonstrated cannabis to be more effective than other analgesics to treat chronic pain associated with certain conditions. However, the existing research lacks large-scale, controlled experiments relating medical cannabis use to pain management. Additionally, negative effects are documented with respect to cannabis use among adolescents and those suffering from compromised mental health. There is a need for further research on the topic.

View this review (yellow link) or download:

This paper is also stored here: http://bit.ly/2wtvpRY inside the CED Foundation Archive

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Benjamin Caplan, MDSome, But Not Enough Data on Cannabis for Chronic Pain
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Guanfacine reducing cannabis withdrawal symptoms?

Guanfacine decreases symptoms of cannabis withdrawal in daily cannabis smokers

A study performed on daily cannabis users with cannabis use disorder (CUD) found evidence for Guanfacine to reduce the irritability and disturbances to sleep, characteristic of cannabis withdrawal. It is potentially a viable, improved alternative to Lofexidine, another treatment for CUD which happens to result in some adverse effects, including drowsiness, dizziness, and altered food intake. However, beyond these effects, while Lofexidine reduced cannabis self-administration following abstinence, Guanfacine did not in this study. Regardless, further research on the therapeutic effects of Guanfacine may be worthwhile and could help reduce cannabis cravings following withdrawal.

For the full review & to explore related work:

This paper is also stored here: http://bit.ly/2wsKbZh inside the CED Foundation Archive

Benjamin Caplan, MDGuanfacine reducing cannabis withdrawal symptoms?
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Cannabinoid receptors as therapeutic targets for autoimmune diseases: where do we stand?

Because of the associated anti-inflammatory action, modulation of CB1R & CB2R is helpful to treat autoimmune diseases, including Multiple Sclerosis, Type-1 Diabetes Mellitus, and Rheumatoid Arthritis The full list is truly very much longer, as every illness necessarily involves the immune system and cellular communication.

The following review, written by Elaine D. Gonc ̧alves

The following review, written by Daphna Katz-Talmor: (yes, same name, unfortunately!)

Benjamin Caplan, MDCannabinoid receptors as therapeutic targets for autoimmune diseases: where do we stand?
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Video: Medical Marijuana: What Physicians Need to Know

A video adaptation of “Medical Marijuana: What Physicians Need to Know”

This paper is also stored here:   (http://bit.ly/2KxqoAe)      inside the CED Foundation Archive

To explore related information, click the keywords below:

Benjamin Caplan, MDVideo: Medical Marijuana: What Physicians Need to Know
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Certain Cannabinoids may be Effective Co-Therapies for Neuropathic or MS pain

In a systematic review of studies investigating cannabis therapy for the treatment of chronic non-cancer pain (CNCP), evidence pointed to cannabinoids primarily effecting change with respect to neuropathy or MS-related pain. For CNCPs, it is unlikely that cannabinoids can be used as a single therapy, but rather in conjunction with other therapies. The quality of evidence in many of the studies reviewed was low, so further research needs to be completed in order to evaluate the efficacy of cannabinoids as a long-term treatment option for CNCPs.

Read more here:

This paper is stored here: http://bit.ly/2IgOLiG inside the CED Foundation Archive To explore related literature, click keywords below:

Benjamin Caplan, MDCertain Cannabinoids may be Effective Co-Therapies for Neuropathic or MS pain
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Biosynthesis of Cannabinoids

Still in the early stages, biosynthesis of cannabinoids using fermentative microbes could diminish dependency on plants to extract cannabinoids and help control dosage for medical patients. This is still in the works but could be very cost efficient long term for all involved http://bit.ly/315Lcof

Benjamin Caplan, MDBiosynthesis of Cannabinoids
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Cannabinoids, Terpenoids, and ALSO flavonoids

I wonder if we should be spending as much time on flavonoids as we do on terpenes (including cannabinoids)?

There is little doubt that they play a powerful effect. Just as the minor cannabinoids tend to be overlooked by much of the general & scientific cultures… flavonoids are also largely passed-over.

This study, for example, indicates that some of the components of dark chocolate reduce the body’s production of the stress hormone, cortisol (not surprising to most who have every consumed chocolate, but… did you know that those components are also found all over nature, including inside cannabis?!)

I’ll start adding flavonoids to the list of info to start sharing!

http://bit.ly/2W6C0w8

Benjamin Caplan, MDCannabinoids, Terpenoids, and ALSO flavonoids
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