All posts tagged: CBD

Analyses of Cannabinoid Signaling in the Immune System Highlights Key Questions, Challenges, and Future Directions

June 24, 2019 Adolescents, Anti-inflammatory properties, Arthritis, Autoimmunity, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Depression, Diabetes, Future Medicine, Neuropathy, Pain, Science, THC

Targeting Cannabinoid Signaling in the Immune System: “High”-ly Exciting Questions, Possibilities, and Challenges

A meta-analysis concerning the role of cannabinoid signaling in immune system regulations revealed current therapeutic benefits, challenges for future research, and exciting new directions. Among the current research, cannabinoids have already been found to suppress inflammation associated with autoimmune diseases, especially in multiple sclerosis, rheumatoid arthritis, Type-1 Diabetes, and Crohn’s Disease. Future cannabis-based therapies aim to improve immune responses to organ donation, bone marrow transplants, and skin grafts. The analysis includes challenges facing future cannabis research such as potential side effects and legal status.

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Targeting Cannabinoid Signaling in the Immune System- “High”-ly Exciting Questions, Possibilities, and Challenges Download

This paper is also stored here: http://bit.ly/31ArGR9 inside the CED Foundation Archive

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Variations in Genes Influences Cannabis’ Acute Effects on Behavior

June 23, 2019 Addiction, Adolescents, Adverse Effects, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Cortisol, Future Medicine, Memory, Mental Health, Pain, Science, THC

CNR1 and FAAH variation and affective states induced by marijuana smoking

A recent study has revealed that variations within cannabinoid receptor 1 (CBR1) and fatty acid amide hydrolase (FAAH) influences cannabis’ acute effects on affect. Variations of CBR1 and FAAH are known to be associated with cannabis dependence. The current study now adds that the variations in genes also affect an individual’s behavior when ingesting cannabis. The results of this study provide useful information for understanding an individual’s motivation for marijuana use, as well as risks and associated behaviors.

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CNR1 and FAAH variation and affective states induced by marijuana smoking Download

This paper is also stored here: http://bit.ly/31Ce9Za inside the CED Foundation Archive

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Recently Identified Mechanism of Chronic Stress-Induced Pain

June 22, 2019 Addiction, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Cortisol, Depression, Future Medicine, History, Mental Health, Pain, Science, Stress, THC

Chronic Stress Is Associated with Pain Precipitation and Elevation in DeltaFosb Expression

Researchers have identified Delta-FosB, an osteosarcoma viral oncogene, as a useful molecular marker of sustained pain. The expression of Delta-FosB is significantly elevated by stress-induced pain, exposing its role in the adaptability of nerves. This study supports theories that Delta-FosB plays an important role in drug addiction, depression, and stress adaptation. The interaction between stress, depression, and pain is something that is not yet well-understood. But, as we learn more about cannabis-based medicine, many of the age-old questions about pain have become much clearer.

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Chronic Stress Is Associated with Pain Precipitation and Elevation in DeltaFosb Expression Download

This paper is also stored here: http://bit.ly/31A7Y86 inside the CED Foundation Archive

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Pregnant women are using more cannabis over time

June 21, 2019 Adverse Effects, Cannabinoids, Cannabis Education, Cannabis News, Cannabis Science, CB1, CB2, CBD, Citizen Science, Future Medicine, News, Pregnancy, Regulation, Stigma, THC, Women in Cannabis

Statistics show that in the past 15 years, the number of pregnant women using marijuana, especially in their first trimester, has risen greatly. These numbers may be slightly skewed, but they show the importance of more research being done on the effect of cannabis on pregnant women. https://cnn.it/2WWQV1e

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Tetrahydrocannabinol and cannabidiol as potential curative agents for cancer. A critical examination of the preclinical literature.

June 21, 2019 Animal Model, Cancer, Cannabinoids, Cannabis Science, CBD, Future Medicine, THC

According to multiple mouse-models, THC administered directly into cancerous tumors produces a reduction in tumor sizes.

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∆ 9 -tetrahydrocannabinol and cannabidiol as potential curative agents for cancer. A critical examination of the preclinical literature Download

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CBD Overcomes Resistance to current treatment of Human Colorectal Cancer Cells

June 21, 2019 Aging, Cancer, Cannabis, Cannabis Science, CBD, Elderly, Future Medicine, Science

Oxaliplatin is the most commonly used drug to treat colorectal cancer (CRC), but patients often develop resistance to it. So, researchers conducted a study to determine the effect of CBD in overcoming oxaliplatin resistance in CRC cells. They found that elevated NOS3 phosphorylation is an essential part of the development of oxaliplatin resistance, and CBD successfully decreased NOS3 phosphorylation. This effect resulted in cells overcoming oxaliplatin resistance, which suggests that CBD could be a new strategy to treat colorectal cancer.

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Cannabidiol Overcomes Oxaliplatin Resistance by Enhancing NOS3- and SOD2-Induced Autophagy in Human Colorectal Cancer Cells Download

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Cannabinoid Receptors Working with Opioid Receptors

June 21, 2019 Addiction, Adolescents, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Future Medicine, Memory, Neuropathy, Opiates, Science

The locus coeruleus is a spot in the human brainstem that is integral to our responses to stress, panic, wakefulness, and sleep-wake transitions. Both the cannabinoid receptors and opioid receptors in the locus coeruleus have a synergistic relationship that, once the medical system begins to incorporate more education about cannabinoids, just might change how physicians prescribe pain medication. The interactions of the two receptor types provide a mechanism that could easily and conveniently improve pain control, provide treatments for addiction, and will likely aid those experiencing symptoms of withdrawal. Research focusing on the treatment of opioid addiction with cannabis is ongoing… but hindered by the legal status of cannabis.

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Characterization of cannabinoid-1 receptors in the locus coeruleus relationship with mu-opioid receptors Download

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Cannabinoid Hyperemesis Syndrome is Frequently Misdiagnosed as Cyclic Vomiting Syndrome

June 20, 2019 Abuse, Adverse Effects, Anxiety, Cannabinoids, Cannabis, Cannabis Education, Cannabis Hyperemesis Syndrome, Cannabis Science, Cannabis Use Disorder (CUD), CBD, Heavy Use, THC, Withdrawal

Association of Marijuana Use and Cyclic Vomiting Syndrome

A recent study has found that a subset of patients diagnosed with Cyclic Vomiting Syndrome actually suffers from Cannabinoid Hyperemesis Syndrome. Cannabinoid Hyperemesis Syndrome is a rare condition that primarily occurs in daily, long-term users of cannabis, more common among males than females. Chronic cannabis consumers should inform their physicians of any illicit drug use, as well as any cannabis consumption, during routine check-ups and/or emergency room visits, to ensure accurate diagnoses can be made.

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Association of Marijuana Use and Cyclic Vomiting Syndrome Download

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Safety and Efficacy of Medical Cannabis in Fibromyalgia

June 20, 2019 Anxiety, Behavior change, Bipolar Disorder, Cannabinoids, Cannabis, Cannabis News, Cannabis Science, CBD, Depression, Fibromyalgia, Future Medicine, Science, THC

Another study with promising results for the use of cannabis to treat chronic pain and fibromyalgia-related symptoms. A large majority of participants reported improved sleep, depression-related symptoms, quality of life and over 20% stopped or reduced the dosage of opioids. https://prn.to/2KXUQUe

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CED Foundation Archive

June 19, 2019 Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, CBD, CED In The News, Citizen Science, Science, Social Equity, Social Justice, THC

This week, CED Foundation added 77 more #cannabis studies, & 50 about #flavonoids. Read & search for free, and please consider uploading so that others may enjoy the materials you have! This week’s folder: http://bit.ly/2KYfOCF For the whole archive: http://tinyurl.com/MMJarchive