All posts tagged: CB1

Researchers Look to CBD and THC for the Treatment of Chronic Pain

June 17, 2019 Adverse Effects, Arthritis, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Future Medicine, Pain, Products, Science

Efficacy and safety of cannabidiol followed by an open-label add-on of tetrahydrocannabinol for the treatment of chronic pain in patients with rheumatoid arthritis or ankylosing spondylitis: protocol for a multicentre, randomized, placebo-controlled study

Current researchers have proposed a study protocol that would expose any possible benefits of cannabidiol (CBD) and tetrahydrocannabinol (THC) for the treatment of chronic pain in patients suffering from rheumatoid arthritis (RA) and ankylosing spondylitis (AS). This new study hopes to identify how medical cannabis affects pain and cognitive function in RA and AS and provide evidence that cannabis-based pain medication is an alternative to opioids with fewer risks.

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High-potency cannabis and incident psychosis: correcting the causal assumption

June 15, 2019 Adverse Effects, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Education, Cannabis News, CB1, CB2, CBD, Cognition, DSM-5, Hypomania, Mental Health, Psychosis, Schizophrenia, THC

Scientists offer a strong counter-position to the belief that cannabis causes psychosis, pointing out the difference between correlation and causation. They argue that smoke exposure from any source (including cigarettes) could explain the reported link between cannabis and psychosis.

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High-potency cannabis and incident psychosis- correcting the causal assumption Download

This paper is also stored here: http://bit.ly/2WHtDr8 inside the CED Foundation Archive

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Flavonoids May Provide Therapeutic Benefits for Type 2 Diabetes

June 14, 2019 Anti-inflammatory properties, Autoimmunity, Cannabis, Cannabis Education, Cannabis Science, CB1, CB2, CBD, Diabetes, Extraction, Flavonoids, Future Medicine, Non-Cannabis Plant, Placebo-Controlled, Processing, Products, Science

A recent study has found that flavonoids isolated from Psoralea corylifolia are able to inhibit part of the insulin pathway.

Seeds of the P. corylifolia plant have been used in eastern medicine, primary in China, for years, and is now being further researched as flavonoids continue to intrigue researchers with their possible therapeutic benefits. The inhibitory activity found in this study provides evidence that flavonoids should be pursued as a potential treatment for Type-2 Diabetes.

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New compounds from the seeds of Psoralea Corylifolia with their protein tyrosine phosphatase 1B inhibitory activity Download

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New Extraction Methods for “Polyphenols” Benefits Future Research

June 14, 2019 Anti-inflammatory properties, Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, CB1, CB2, CBD, Diabetes, Extraction, Flavonoids, Future Medicine, Obesity, Processing, Science, Terpenes

Citrus peels waste as a source of value-added compounds- extraction and quantification of bioactive polyphenols

A recent study has exposed a more efficient, sustainable, and economically viable extraction method for polyphenols (specific active chemical compounds) from citrus peels. One such polyphenol is Naringin, a flavonoid present in lemon peels, which has been hypothesized to have anti-inflammatory and antioxidant effects, as well as, potentially, to help treat obesity. This new extraction method will allow researchers to discover more definite therapeutic effects of polyphenols in citrus peels.

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Citrus peels waste as a source of value-added compounds- extraction and quantification of bioactive polyphenols Download

This paper is also stored here: http://bit.ly/2F7XrXY inside the CED Foundation Archive

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Cannabidiol (CBD) as an Adjunctive Therapy in Schizophrenia: A Multicenter Randomized Controlled Trial

June 14, 2019 Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, DSM-5, Future Medicine, Mental Health, Placebo-Controlled, Science

A 2018 study showed that, for patients with schizophrenia, adding CBD to ongoing antipsychotic treatment reduced psychotic activity, as compared to placebo add-on

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Cannabidiol (CBD) as an Adjunctive Therapy in Schizophrenia- A Multicenter Randomized Controlled Trial Download

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CBD reduces seizures and social deficits in a mouse model of Dravet syndrome

June 13, 2019 Animal Model, Autism, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Future Medicine, Science

CBD treatment in a mouse model for Dravet Syndrome effectively reduced seizures and autism-like behaviors

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Cannabidiol attenuates seizures and social deficits in Dravet mice Download

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Cannabinoids in Attention- Deficit/Hyperactivity Disorder: A randomized-controlled trial

June 13, 2019 ADD/ADHD, Adolescents, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, Future Medicine, Mental Health, Pediatrics, Placebo-Controlled, Science, Survey, THC

In a placebo-controlled study of a cannabis oral spray in patients with ADHD, there was no significant improvement in cognitive performance, but there was a significant improvement in hyperactivity and impulsivity.

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Cannabinoids in Attention- Deficit/Hyperactivity Disorder: A randomized-controlled trial Download

A slideshow of this study: Download

This paper is also stored here: http://bit.ly/31ykZiz inside the CED Foundation Archive

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Cannabidiol in Anxiety and Sleep: A Large Case Series

June 13, 2019 Anxiety, Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, CB1, CB2, CBD, Cognition, Future Medicine, Insomnia, Science, Sleep, Sleep Apnea, Stress, THC

In a study of 72 psychiatric patients given CBD in capsule form, researchers found that cannabidiol successfully decreased anxiety and improved sleep over the course of three months.

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Cannabidiol in Anxiety and Sleep- A Large Case Series Download

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The Endocannabinoid System: A New Treatment Target for Obsessive Compulsive Disorder?

June 13, 2019 Behavior change, Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, CB1, CB2, CBD, Cognition, Future Medicine, OCD, Science, THC

Animal models show that cannabis has anti-compulsive effects, and OCD patients say that cannabis improves their symptoms. Now scientists are asking for more research.

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The Endocannabinoid System- A New Treatment Target for Obsessive Compulsive Disorder?Download

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Influence of the CB1 cannabinoid receptors & antidepressant effects

June 11, 2019 Adolescents, Anti-inflammatory properties, Behavior change, Bipolar Disorder, Cannabinoids, Cannabis, Cannabis Science, CB1, CBD, Depression, DSM-5, Future Medicine, Mood, Stigma, Stress, THC

Study finds that, for patients already taking antidepressants, activating and/or prohibiting the CB1 receptor in the brain might make those antidepressants more effective.

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Influence of the CB1 cannabinoid receptors on the activity of the monoaminergic system in the behavioral tests in mice
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