THC

The Cannabinoid System is a Promising Source of Targets for Treating Pain

June 28, 2019 Addiction, Adverse Effects, Anti-inflammatory properties, Anxiety, Arthritis, Autoimmunity, Blood-Levels, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Citizen Science, Cognition, Elderly, Future Medicine, Memory, Multiple Sclerosis, Muscle Pain, Neuropathy, Occasional Use, Opiates, Overdose, Pain, Placebo-Controlled, Products, Regulation, Science, Stigma, Stress, THC

A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain ECS

The cannabinoid system provides momentum to develop cannabinoid-based medications to treat inflammatory and neuropathic pain as researchers continue to find promising therapeutic targets. These new targets may lead to the formation of novel pain-relief medications that may serve well to alleviate pain for those suffering from cancer, multiple sclerosis, and fibromyalgia. Cannabis-based pain medicine is also being researched for opioid-sparing effects and effectiveness in reducing the necessary dose of opioids.

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A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain ECS Download

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Cannabis Cafes coming to MA

June 26, 2019 Behavior change, Cannabis, Cannabis News, Future Medicine, History, Law, Legislation, Massachusetts, Occasional Use, Politics, Regulation, Social Consumption / Cafés, Social Justice, THC

Massachusetts has come one step closer to a pilot program involving cannabis cafes across the state. This will also bring about more licenses for cannabis delivery and social consumption, as a less capital-intensive option for entrepreneurs to enter the industry. http://bit.ly/2IOjOUz

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Video: The Endocannabinoid System’s Intriguing Role in Gut Health

June 26, 2019 Animal Model, Anti-inflammatory properties, Antibiotic, Autoimmunity, Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, CB1, CB2, CBD, Future Medicine, Gastrointestinal Effects, IBS, Neuropathy, Science, Stress, THC, Video

A 2018 literature review summarizes the findings on cannabis and gut health. The endocannabinoid system plays a key role in gut motility, obesity, and inflammatory bowel disease (IBD). Targeting the endocannabinoid system with CBD oil or other cannabinoids seems to reduce colonic inflammation and relieve stress, at a microscopic level, inside the gastrointestinal tract. Watch our video adaptation of the effects of cannabis on IBD:

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This paper is also stored here: http://bit.ly/2IQCNy1 inside the CED Foundation Archive

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CBD antibacterial properties, topically

June 25, 2019 Anti-inflammatory properties, Antibiotic, Cannabinoids, Cannabis News, Cannabis Science, Case Study, CB1, CB2, CBD, Flavonoids, Future Medicine, Infectious Disease, Products, Science, THC

Preliminary testing shows positive results towards using CBD as an antibiotic topically, but also potentially to deal with systematic infections, such as pneumonia, using oral dosing. One of the present concerns is the struggle of getting permits to handle these cannabinoids to do further testing.

While these specific findings have not yet been published in a peer-review journal, this is far from the first time we have seen antimicrobial activity associated with plants or with cannabis. Evolutionarily, this trait is believed to be adaptive for the plant, and within cannabinoid, terpenoid, and flavonoid compounds, this activity has been demonstrated reproducibly, both in the lab and in clinic.
http://bit.ly/2LbTwxm

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Cannabinoids + opioid pain relief: subjective effects in healthy humans

June 25, 2019 Anti-inflammatory properties, Arthritis, Cannabinoids, Cannabis Science, Case Study, Dronabinol, Muscle Pain, Neuropathy, Opiates, Pain, Science, Synthetic Cannabinoids, THC

Human study finds that, when taken with opioids, dronabinol (THC) may increase impairment and decrease, or not affect, pain relief. Researchers conclude that THC might NOT protect the body from the adverse effects of opioids. However, the study examined only 10 participants, and such a small sample size should give pause to the validity and applicability of the findings.

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Cannabinoid modulation of opioid analgesia and subjective drug effects in healthy humans Download

This paper is also stored here: http://bit.ly/2IHJuSO inside the CED Foundation Archive

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Video: Cannabis and Multiple Sclerosis

June 24, 2019 Adverse Effects, Aging, Anti-inflammatory properties, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, CB1, CB2, CBD, CED Clinic, Dr Caplan, Future Medicine, Insomnia, Multiple Sclerosis, Muscle Pain, Neuropathy, Pain, Science, Sleep, Stigma, THC, Video

A 2019 literature review summarizes the findings on cannabis use for patients with multiple sclerosis. Cannabis has been shown to aid a number of symptoms associated with multiple sclerosis, including chronic pain, spasticity, and problems with sleep. To learn more, check out our video adaptation below:

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This paper is also stored here: http://bit.ly/2IJAqNz inside the CED Foundation Archive

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Cannabis constituent synergy in a mouse neuropathic pain model

June 24, 2019 Anti-inflammatory properties, Anxiety, Autoimmunity, Behavior change, Cannabinoids, Cannabis Education, Cannabis Science, CB1, CB2, CBD, Future Medicine, Muscle Pain, Neuropathy, Pain, Science, THC

In a mice-model study, researchers found that low dose THC:CBD might successfully treat neuropathic pain.

Neuropathic pain is pain caused by damage to the somatosensory nervous system. Neuropathic pain may be associated with abnormal sensations or pain from normally non-painful stimuli, for example, Phantom Limb Syndrome.

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Analyses of Cannabinoid Signaling in the Immune System Highlights Key Questions, Challenges, and Future Directions

June 24, 2019 Adolescents, Anti-inflammatory properties, Arthritis, Autoimmunity, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Depression, Diabetes, Future Medicine, Neuropathy, Pain, Science, THC

Targeting Cannabinoid Signaling in the Immune System: “High”-ly Exciting Questions, Possibilities, and Challenges

A meta-analysis concerning the role of cannabinoid signaling in immune system regulations revealed current therapeutic benefits, challenges for future research, and exciting new directions. Among the current research, cannabinoids have already been found to suppress inflammation associated with autoimmune diseases, especially in multiple sclerosis, rheumatoid arthritis, Type-1 Diabetes, and Crohn’s Disease. Future cannabis-based therapies aim to improve immune responses to organ donation, bone marrow transplants, and skin grafts. The analysis includes challenges facing future cannabis research such as potential side effects and legal status.

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Targeting Cannabinoid Signaling in the Immune System- “High”-ly Exciting Questions, Possibilities, and Challenges Download

This paper is also stored here: http://bit.ly/31ArGR9 inside the CED Foundation Archive

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Variations in Genes Influences Cannabis’ Acute Effects on Behavior

June 23, 2019 Addiction, Adolescents, Adverse Effects, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Cortisol, Future Medicine, Memory, Mental Health, Pain, Science, THC

CNR1 and FAAH variation and affective states induced by marijuana smoking

A recent study has revealed that variations within cannabinoid receptor 1 (CBR1) and fatty acid amide hydrolase (FAAH) influences cannabis’ acute effects on affect. Variations of CBR1 and FAAH are known to be associated with cannabis dependence. The current study now adds that the variations in genes also affect an individual’s behavior when ingesting cannabis. The results of this study provide useful information for understanding an individual’s motivation for marijuana use, as well as risks and associated behaviors.

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CNR1 and FAAH variation and affective states induced by marijuana smoking Download

This paper is also stored here: http://bit.ly/31Ce9Za inside the CED Foundation Archive

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Earliest evidence for cannabis smoking discovered in ancient tombs

June 22, 2019 Archeology, Asia, Cannabis, Cannabis News, THC

https://www.nationalgeographic.com/culture/2019/06/earliest-evidence-cannabis-marijuana-smoking-china-tombs/

The earliest evidence for human consumption of cannabis has been discovered in a 2,500-year-old cemetery in Central Asia. The traces of cannabis feature higher levels of THC than have been found at any other ancient site, suggesting that people could have intentionally cultivated certain strains of cannabis for a potent high.