Elderly

THC Has Potential for Treating Agitation in Alzheimer’s Disease

June 24, 2019 Aging, Agitation, Alzheimer's Disease, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, Case Study, Cognition, Elderly, Future Medicine, Insomnia, Memory, Nabilone, Stigma, Synthetic Cannabinoids

In a crossover trial of 39 patients with Alzheimer’s disease, treatment with nabilone (a synthetic THC analog) was associated with significant improvement in agitation and, remarkably, cognition. Further studies should examine the effects of both THC and CBD in patients with Alzheimer’s disease because anxiety is common in dementia and may exacerbate agitation.

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Tetrahydrocannabinol Has Potential for Treating Agitation in Alzheimer’s Disease Download

This paper is also stored here: http://bit.ly/2IH2BfX inside the CED Foundation Archive

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CBD Overcomes Resistance to current treatment of Human Colorectal Cancer Cells

June 21, 2019 Aging, Cancer, Cannabis, Cannabis Science, CBD, Elderly, Future Medicine, Science

Oxaliplatin is the most commonly used drug to treat colorectal cancer (CRC), but patients often develop resistance to it. So, researchers conducted a study to determine the effect of CBD in overcoming oxaliplatin resistance in CRC cells. They found that elevated NOS3 phosphorylation is an essential part of the development of oxaliplatin resistance, and CBD successfully decreased NOS3 phosphorylation. This effect resulted in cells overcoming oxaliplatin resistance, which suggests that CBD could be a new strategy to treat colorectal cancer.

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Cannabidiol Overcomes Oxaliplatin Resistance by Enhancing NOS3- and SOD2-Induced Autophagy in Human Colorectal Cancer Cells Download

This paper is also stored here: http://bit.ly/2IwfVn9 inside the CED Foundation Archive

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There’s Growing Evidence Cannabis Helps Older Adults Keep Their Jobs for Years Longer

June 20, 2019 Aging, Cannabis News, Elderly, Jobs, Social Equity

In the US, the largest increase in cannabis use was seen in the older adult population. And with medical cannabis reducing pain associated with work, researchers wonder if cannabis could postpone retirement plans and enhance the US labor supply.
https://www.greenentrepreneur.com/article/335478

Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer’s Disease

June 19, 2019 Alzheimer's Disease, Anti-inflammatory properties, Arthritis, Cannabinoids, Cannabis, Cannabis Science, CBD, Elderly, Future Medicine, Memory, Neuropathy

Researchers find 9 cannabinoids that might protect the brain against toxicities associated with aging. These non-intoxicating cannabinoids are potential drug candidates for Alzheimer’s Disease, and they might also be options for other neurodegenerative diseases, too

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Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer’s Disease Download

This paper is also stored here: http://bit.ly/2L9GccX inside the CED Foundation Archive

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Evidence for Therapeutic Benefits of Cannabidiol, Including Treatment of Ischemic Strokes

June 17, 2019 Adolescents, Adverse Effects, Alzheimer's Disease, Anti-inflammatory properties, Autoimmunity, Behavior change, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Concussion, Elderly, Future Medicine, Heavy Use, Insomnia, Memory, Mental Health, Neuropathy, Pain, Stigma, THC

Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke

Cannabidiol (CBD) has a unique therapeutic profile as it has a cannabinoid receptor-independent mechanism, limited side-effects, and patients do not seem to develop an insurmountable tolerance. Research currently focussed on the therapeutic benefits of CBD has demonstrated long-lasting neuroprotective properties against global and focal ischemic injury, such as ischemic stroke. This piece points to CBD as a major component of cannabis-based medicine as a non-psychoactive component. Further research is needed to evaluate the full clinical capabilities of CBD, including its neuroprotective effect.

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The US patent on Cannabinoids as Antioxidants and Neuroprotectants, from 1999: https://patents.google.com/patent/US6630507B1/en

This paper is also stored here: http://bit.ly/2L0PBn3 inside the CED Foundation Archive

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The Education of Dispensary Staff is Varied and Lacks Regulation

June 17, 2019 Adolescents, Anti-inflammatory properties, Anxiety, Arthritis, Behavior change, Cannabinoids, Cannabis, Cannabis Education, Cannabis News, CBD, Citizen Science, Depression, Dispensaries, Elderly, Future Medicine, History, Legislation, Mental Health, Mood, Neuropathy, Obesity, Pain, Pediatrics, Politics, Regulation, Science, Social Equity, Social Justice, Stigma, THC, Withdrawal, Women in Cannabis

Training and Practices of Cannabis Dispensary Staff

How much medical training does your local budtender possess? An online survey sent to medical marijuana dispensary staff reported only 55% of staffers had any formal training for their position, with 20% reporting some background in medical/scientific training. The analysis reported that many among the dispensary staff are recommending cannabis choices that are consistent with current evidence, but some are recommending strains that are either ineffective or exacerbate a patient’s condition. The findings of this study stress the importance of consistent and well-regulated training of dispensary staff.

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Organ Donors can Safely Consume Cannabis

June 16, 2019 Adverse Effects, Aging, Cannabinoids, Cannabis, Cannabis Science, Cannabis Use Disorder (CUD), CBD, Cocaine, Elderly, Future Medicine, Heavy Use, Illicit Drug Use, Occasional Use, Opiates, Products, Science

Effects of Drug Abuse, Smoking and Alcohol on Donor Hearts and Lungs

A review article that discusses how drug use can affect donor organs has revealed that receiving organs, such as a heart or lungs, from a donor who has used cannabis does not add risk to the procedure. A careful assessment of any donor organ should still be conducted, but having a history of cannabis use does not prevent someone from safely donating.

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Effects of Drug Abuse, Smoking and Alcohol on Donor Hearts and Lungs Download

This paper is also stored here: http://bit.ly/2KPxsIx inside the CED Foundation Archive

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Cognitive Function in Aging Cocaine Smokers is Marginally Lower than Controls

June 15, 2019 Abuse, Adverse Effects, Aging, Behavior change, Cocaine, Cognition, DSM-5, Elderly, Heavy Use, Memory, Occasional Use, Placebo-Controlled, Products, Science

Cognitive function in aging cocaine smokers

A recently published study looking to expose the functional status of older drug users has found that most of their cognitive abilities are equal to their peers who have never smoked cocaine, except for a marginally lower verbal comprehension. Similar studies should continue in order to determine how chronic drug users will affect or challenge public health systems in the future.

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Video: Cannabis For Symptoms of chronic pain, seizures, and inflammation

June 10, 2019 Adverse Effects, Anti-inflammatory properties, Anxiety, Arthritis, Cannabinoids, Cannabis, Cannabis Education, Cannabis News, Cannabis Science, CB1, CB2, CBD, Citizen Science, Depression, Dronabinol, Elderly, Flavonoids, Future Medicine, Heavy Use, History, IBS, Insomnia, Neuropathy, Occasional Use, Opiates, Overdose, Pain, Psychosis, Schizophrenia, Science, Sleep, Stigma, THC, Withdrawal

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Preferences for Medical Marijuana over Prescription Medications Among Persons Living with Chronic Conditions- Alternative, Complementary, and Tapering Uses Download

This paper is also stored here: http://bit.ly/2l4sexZ inside the CED Foundation Archive

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Guanfacine reducing cannabis withdrawal symptoms?

June 10, 2019 Adverse Effects, Cannabinoids, Cannabis, Cannabis Science, Cannabis Use Disorder (CUD), Elderly, Future Medicine, Heavy Use, Products, Withdrawal

Guanfacine decreases symptoms of cannabis withdrawal in daily cannabis smokers

A study performed on daily cannabis users with cannabis use disorder (CUD) found evidence for Guanfacine to reduce the irritability and disturbances to sleep, characteristic of cannabis withdrawal. It is potentially a viable, improved alternative to Lofexidine, another treatment for CUD which happens to result in some adverse effects, including drowsiness, dizziness, and altered food intake. However, beyond these effects, while Lofexidine reduced cannabis self-administration following abstinence, Guanfacine did not in this study. Regardless, further research on the therapeutic effects of Guanfacine may be worthwhile and could help reduce cannabis cravings following withdrawal.

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Guanfacine decreases symptoms of cannabis withdrawal in daily cannabis smokers Download

This paper is also stored here: http://bit.ly/2wsKbZh inside the CED Foundation Archive