Adverse Effects

Adolescent E-Cigarette Use Increased by 78%

July 4, 2019 Abuse, Addiction, Adolescents, Adverse Effects, Cannabis News, Heavy Use, Illicit Drug Use, Legislation, Regulation, Science, Social Justice, Tobacco

Characteristics of Daily E-Cigarette Use and Acquisition Means Among a National Sample of Adolescents

From 2017 to 2018 the amount of middle school and high school electronic cigarette (e-cigarette) users increased by 48% and 78% respectively. One of the first studies examining the association between e-cigarette characteristics and daily use among US adolescents is calling for comprehensive tobacco control efforts to reduce e-cigarette and nicotine addiction among adolescents. 38% of adolescent users report using their e-cigarette devices for cannabis which can be hazardous due to the lack of regulation. The potential risks associated with nicotine use and the dangerous misuse of these devices for other substances is putting youth’s health at risk.

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Characteristics of Daily E-Cigarette Use and Acquisition Means Among a National Sample of Adolescents Download

This paper is also stored here: http://bit.ly/2Ff733m inside the CED Foundation Archive

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Sex differences in the anxiety effects of cannabinoids

July 1, 2019 Addiction, Adverse Effects, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, Citizen Science, Gender, Illicit Drug Use, Science

In overarching trends, one pattern that is seen in the medical literature is a greater tendency for males to be more likely to develop drug abuse disorders than female counterparts, whilst females are more likely to develop anxiety disorders than male counterparts.

Of course, these trends are merely observational patterns in the current literature, which represents a biased perspective of biased subjects, and certainly not etched in stone. Further, many people do not conform to one pre-determined organization system as simple as gender to help educate whether they would be likely to develop drug dependence or anxiety, and even others don’t conform to a single gender. So, a sizeable grain of salt must be taken with what we understand from this literature.

That given, the relevant punch line here is what role might cannabis play in inducing or reducing anxiety across sexes, and how does cannabis might relate to addiction/dependence.

We are still at early stages of these important questions, but one recent study found, that female rats were significantly more likely than male rats to experience anxiety when given large doses of cannabis.

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Sex-Differences-in-the-Anxiety-Effects-of-Cannabinoids Download

This paper is also stored here: http://bit.ly/2J15XdL inside the CED Foundation Archive

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Development of Cannabis-Based Treatment for Bipolar Disorder

June 30, 2019 Addiction, Adolescents, Adverse Effects, Anxiety, Bipolar Disorder, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Cognition, Depression, DSM-5, Elderly, Future Medicine, Hypomania, Mental Health, Mood, Neuropathy, Science, THC

Bipolar disorder and the endocannabinoid system

A recently published article serves as a call for research to be conducted to discover how cannabis could impact the management of bipolar disorder (BD). Presented in the article is a full review of the advantages and disadvantages of cannabis-based medicine in the treatment of BD and provides insight into possible mechanisms might affect the pathophysiology of the disorder. The insights listed within the article provide the rationale for examining the endocannabinoid system, specifically the cannabinoid receptor 2, with the hopes of finding therapeutic targets for mood control associated with BD.

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Bipolar disorder and the endocannabinoid system Download

This paper is also stored here: http://bit.ly/2FfJXK6 inside the CED Foundation Archive

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Cannabis use as a risk factor for causing motor vehicle crashes: a prospective study

June 28, 2019 Adverse Effects, Canada, Cannabis Education, Cannabis Science, Driving, Future Medicine, History, Legislation, Reaction Time, Regulation, Social Justice, Stigma

Title of study: Cannabis use as a risk factor for causing motor vehicle crashes: a prospective study

After legalization in 2018, many Canadian provinces implemented “zero tolerance” policies for drivers who have THC in their systems. But a new study from the University of British Columbia suggests that Canada’s drug-impaired driving laws may be unnecessarily strict. According to researchers, there is no link between THC levels below 5ng/mL and increased risk of car accidents.

Note: Considering the potentially grave risk to life and health for modern culture to make the wrong interpretation of the potential dangers of the effects of cannabis consumption on driving, it is critical for the industry to approach the circumstances with delicacy and diligence. Ideally, everyone involved will be motivated to learn as much as possible about the impact of cannabis on the risks of operating machinery and all will follow a cautious approach which will minimize the risk to all. To that end, it is important to consider and reconcile evidence from multiple perspectives.

The article:

“New study suggests low levels of THC in blood do not increase risk of car crash” https://www.straight.com/cannabis/1256476/new-study-suggests-low-levels-thc-blood-do-not-increase-risk-car-crash#

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Cannabis use as a risk factor for causing motor vehicle crashes- a prospective study Download

This paper is also stored here: http://bit.ly/2IVhSJY inside the CED Foundation Archive

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Looking for a genetic explanation for “Cannabis Use Disorder”

June 28, 2019 Addiction, Adverse Effects, Behavior change, Cannabis, Cannabis Dependence, Cannabis Science, Cannabis Use Disorder (CUD), Heavy Use, Science, Stigma

Genome-wide association study implicates CHRNA2 in Cannabis Use Disorder

Roughly 9% of cannabis users become dependent. In a recent study, scientists identified a significant association between CHRNA2 gene expression and a diagnosis of Cannabis Use Disorder. In other words, genetics might help to explain why some people may find themselves more dependent upon cannabis than others.

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Genome-wide association study implicates CHRNA2 in cannabis use disorder Download

This paper is also stored here: http://bit.ly/2IVZJvJ inside the CED Foundation Archive

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The Cannabinoid System is a Promising Source of Targets for Treating Pain

June 28, 2019 Addiction, Adverse Effects, Anti-inflammatory properties, Anxiety, Arthritis, Autoimmunity, Blood-Levels, Cannabinoids, Cannabis, Cannabis Science, CB1, CB2, CBD, Citizen Science, Cognition, Elderly, Future Medicine, Memory, Multiple Sclerosis, Muscle Pain, Neuropathy, Occasional Use, Opiates, Overdose, Pain, Placebo-Controlled, Products, Regulation, Science, Stigma, Stress, THC

A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain ECS

The cannabinoid system provides momentum to develop cannabinoid-based medications to treat inflammatory and neuropathic pain as researchers continue to find promising therapeutic targets. These new targets may lead to the formation of novel pain-relief medications that may serve well to alleviate pain for those suffering from cancer, multiple sclerosis, and fibromyalgia. Cannabis-based pain medicine is also being researched for opioid-sparing effects and effectiveness in reducing the necessary dose of opioids.

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A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain ECS Download

This paper is also stored here: http://bit.ly/2FfLorA inside the CED Foundation Archive

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Neem Oil vs Cannabinoid Hyperemesis Syndrome

June 26, 2019 Adverse Effects, Cannabis, Cannabis Education, Cannabis Hyperemesis Syndrome, Cannabis Science, Cannabis Use Disorder (CUD), Heavy Use, Neem Oil, Occasional Use, Products

Some people are concerned that Cannabinoid Hyperemesis Syndrome (CHS,) a rare condition involving cyclical vomiting, may be caused by neem oil or pesticides. However, symptoms are more consistent with an overload of CB1 receptors, circumstances that occur primarily with habitual, large-volume consumers. Here, an interesting review of the ongoing public conversation: http://bit.ly/2LepwAV

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Case Studies Expose Under Recognition of Cannabis Hyperemesis Syndrome

June 25, 2019 Adverse Effects, Cannabis Hyperemesis Syndrome, Cannabis Use Disorder (CUD), Capsaicin, Case Study, Citizen Science, Heavy Use, Science

“Cannabis hyperemesis syndrome: still under-recognized after all these years“

After two years of chronic vomiting and pain and dozens of trips to emergency rooms a 23-year-old woman was found to have cannabis hyperemesis syndrome (CHS). Physicians are still unable to recognize the early symptoms of CHS as cannabis use is still in a legal gray area in much of the country. A lack of research, recognition, and trust often prevents a quick diagnosis when an illness is related to cannabis, leading to multiple referrals and invasive tests.

CHS was first described 15 years ago yet it is not frequently recognized in patients. The case study featured in this blog post highlights patients and physicians’ outcry for tolerance and support so that cannabis-related illnesses can be efficiently and effectively engaged.

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Cannabis hyperemesis syndrome: still under recognised after all these years Download

This paper is also stored here: http://bit.ly/2IxMxNx inside the CED Foundation Archive

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Video: Cannabis and Multiple Sclerosis

June 24, 2019 Adverse Effects, Aging, Anti-inflammatory properties, Anxiety, Behavior change, Cannabinoids, Cannabis, Cannabis Education, Cannabis Science, CB1, CB2, CBD, CED Clinic, Dr Caplan, Future Medicine, Insomnia, Multiple Sclerosis, Muscle Pain, Neuropathy, Pain, Science, Sleep, Stigma, THC, Video

A 2019 literature review summarizes the findings on cannabis use for patients with multiple sclerosis. Cannabis has been shown to aid a number of symptoms associated with multiple sclerosis, including chronic pain, spasticity, and problems with sleep. To learn more, check out our video adaptation below:

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Cannabis and Multiple Sclerosis Download

This paper is also stored here: http://bit.ly/2IJAqNz inside the CED Foundation Archive

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Should donors who have used marijuana be considered candidates for living kidney donation?

June 24, 2019 Adverse Effects, Anti-inflammatory properties, Cannabinoids, Cannabis, Cannabis News, Cannabis Science, Future Medicine, Organ Donation, Social Justice, Stigma, Testing

Although tobacco use has been linked to worse outcomes for kidney donors and recipients, cannabis seems to have no effect on post-operation outcomes.

In a retrospective study of 294 kidney transplants, doctors found no short-term or long-term differences in kidney function for donors or recipients.

In other words, cannabis users may safely donate kidneys.

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Should donors who have used marijuana be considered candidates for living kidney donation?Download

This paper is also stored here: http://bit.ly/2IFl0cQ inside the CED Foundation Archive

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