According to multiple mouse-models, THC administered directly into cancerous tumors produces a reduction in tumor sizes.
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Oxaliplatin is the most commonly used drug to treat colorectal cancer (CRC), but patients often develop resistance to it. So, researchers conducted a study to determine the effect of CBD in overcoming oxaliplatin resistance in CRC cells. They found that elevated NOS3 phosphorylation is an essential part of the development of oxaliplatin resistance, and CBD successfully decreased NOS3 phosphorylation. This effect resulted in cells overcoming oxaliplatin resistance, which suggests that CBD could be a new strategy to treat colorectal cancer.
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The locus coeruleus is a spot in the human brainstem that is integral to our responses to stress, panic, wakefulness, and sleep-wake transitions. Both the cannabinoid receptors and opioid receptors in the locus coeruleus have a synergistic relationship that, once the medical system begins to incorporate more education about cannabinoids, just might change how physicians prescribe pain medication. The interactions of the two receptor types provide a mechanism that could easily and conveniently improve pain control, provide treatments for addiction, and will likely aid those experiencing symptoms of withdrawal. Research focusing on the treatment of opioid addiction with cannabis is ongoing… but hindered by the legal status of cannabis.
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This week, Colombia’s Constitutional Court overruled a ban on the public consumption of cannabis. Now, citizens wonder if the government will soon legalize recreational cannabis in addition to the already-legal medical cannabis.
Fueled by CBD product sales and Canada’s recent legalization of marijuana, the world’s cannabis market could total $14.9 billion in 2019, up 36% from 2018, according to a new report released Thursday.
https://www.cnn.com/2019/06/20/tech/cannabis-industry-15-billion/index.html
On Wednesday, House lawmakers explored efforts to ease rules and boost small business owners in the legal cannabis industry. During the hearing before the House Committee, workers from the cannabis industry discussed the financial and legal obstacles they face while running their small businesses.
In the US, the largest increase in cannabis use was seen in the older adult population. And with medical cannabis reducing pain associated with work, researchers wonder if cannabis could postpone retirement plans and enhance the US labor supply.
https://www.greenentrepreneur.com/article/335478
On Monday, the LA City Council decided to allow the city’s original 4 dispensaries to maintain temporary licenses to sell recreational marijuana. The dispensaries were set up in 2003, but in 2016, the council decided that the stores should compete with nearly 100 other dispensaries for just 8 licenses. None of the original stores secured top 8 spots, so now their owners fight to maintain the right to sell cannabis until the 8 other stores open shop.
Despite a poll showing that the majority of New Yorkers support legalization, lawmakers could not agree on a handful of key components of the Marijuana Regulation and Taxation Act (MRTA), thus deciding not to pass the bill.
https://www.leafly.com/news/politics/new-yorks-adult-use-cannabis-legalization-bill-is-dead
Capsaicin Cream for Treatment of CHS adolescent
Researchers have found that capsaicin cream is an effective and safe method of treating cannabinoid hyperemesis syndrome (CHS) in adolescents. Capsaicin cream has previously been shown to be effective at treating CHS in adults but adolescents have previously been treated with haloperidol, a drug known to have serious side effects. Capsaicin cream offers a much safer and more cost-effective method of treatment for adolescents.
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